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东北农业大学向文胜教授论文一字不改照抄别人论文引言

方老师：

    你好！东北农业大学向文胜教授论文抄袭。introduction部分一字不改的抄
袭上海交通大学发表的论文。这样的教授居然评为杰青，今年还参评国家科技奖。

Role of nsdA in negative regulation of antibiotic production and 
morphological differentiation in Streptomyces bingchengensis.
J Antibiot (Tokyo).  2009; 62(6):309-13 (ISSN: 0021-8820)
Wang XJ; Guo SL; Guo WQ; Xi D; Xiang WS
School of Life Science, Northeast Agricultural University, Harbin, 
China.

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR and 
mmyR, are at the bottom of the regulatory network, each controlling 
one antibiotic biosynthetic pathway.3 Global regulators, such as 
bldA,4 bldB,5 bldD6 and bldG,7 perform the highest level regulation 
and affect both morphological and physiological differentiation.8, 9 
At intermediate levels in the regulatory cascades, many regulatory 
genes, such as afsB,10 abaA,11 absB,12 afsK-afsR13, 14 and tcrA,15 and 
two-component systems, such as afsQ1-afsQ2,16 absA1-absA2,17, 18 
cutS-cutR19 and phoR-phoP,20 have been identified, which regulate the 
synthesis of two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP, 
tcrA and some pathway-specific repressors regulate antibiotic 
production in a negative manner, as mutations in these genes resulted 
in the overproduction of the corresponding antibiotic(s). Global 
regulators may also play a negative role, as in the case of the 
A-factor receptor protein, ArpA, in Streptomyces griseus. When 
A-factor is absent, ArpA binds to the adpA promoter and represses the 
expression of AdpA, which is an activator of a regulon that consists 
of operons involved in mycelial differentiation and antibiotic 
production. The arpA-null mutants produced more streptomycin and 
formed aerial hyphae earlier than the wild-type strain did.21, 22, 23 
Recent microarray data have indicated a cross-regulation among 
disparate antibiotic biosynthetic pathways and even some 
backregulation from cluster-situated regulators to a “higher level” 
pleiotropic regulatory gene.24 
The identification of new genes that regulate antibiotic biosynthesis 
and mycelial differentiation is important for understanding the 
factors affecting antibiotic yield. In this study, we report the 
identification of a new gene, nsdA, negatively affecting both processes. 


Identification of a Gene Negatively Affecting Antibiotic Production 
and Morphological Differentiation in Streptomyces coelicolor A3(2)?
Wencheng Li,1 Xin Ying,1 Yuzheng Guo,1 Zhen Yu,1 Xiufen Zhou,1,2 Zixin 
Deng,1,2 Helen Kieser,3 Keith F. Chater,3 andMeifeng Tao1,*
J Bacteriol. 2006 Dec; 188(24): 8368–8375.
Published online 2006 Oct 13. doi:  10.1128/JB.00933-06
PMCID: PMC1698255

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR, and 
mmyR, are at the bottom of the regulatory network, each controlling 
one antibiotic biosynthetic pathway (4). Global regulators, such as 
bldA (16), bldB (14), bldD (15), and bldG (5), perform the 
highest-level regulation and affect both morphological and 
physiological differentiation (9, 10). At intermediate levels in the 
regulatory cascades, many regulatory genes, such as afsB (22), abaA 
(17), absB (7), afsK-afsR (21, 36), and tcrA (33), and two-component 
systems, such as afsQ1-afsQ2 (26), absA1-absA2 (1, 42), cutS-cutR (8), 
and phoR-phoP (44), have been identified that regulate the synthesis 
of two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP, and 
tcrA and some pathway-specific repressors regulate antibiotic 
production in a negative way, since null mutations in these genes 
resulted in the overproduction of the corresponding antibiotic(s). 
Global regulators may also play a negative role, as in the case of the 
A-factor receptor protein ArpA in Streptomyces griseus. When A-factor 
is absent, ArpA binds to the adpA promoter and represses the 
expression of AdpA, which is an activator of a regulon that consists 
of operons involved in mycelial differentiation and antibiotic 
production. arpA-null mutants produced more streptomycin and formed 
aerial hyphae earlier than did the wild-type strain (39). Recent 
microarray data have indicated a cross-regulation among disparate 
antibiotic biosynthetic pathways and even some back regulation from 
cluster-situated regulators to a “higher level” pleiotropic 
regulatory gene (23).
The identification of new genes that regulate antibiotic biosynthesis 
and mycelial differentiation is important for understanding the 
factors affecting antibiotic yield. In this study, we report the 
identification of a new gene negatively affecting both processes.

(XYS20150328)

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